By Eric Maze-Missouri
It’s also the first study to show men and women react differently to these changes.
Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to vascular disease. Researchers examined vascular insulin resistance in 36 young and healthy men and women by exposing them to 10 days of reduced physical activity, cutting their step count from 10,000 to 5,000 steps per day. The participants also increased their sugary beverage intake to six cans of soda per day.
“We know that incidence of insulin resistance and cardiovascular disease is lower in premenopausal women compared to men, but we wanted to see how men and women reacted to reduced physical activity and increased sugar in their diet over a short period of time,” says Camila Manrique-Acevedo, associate professor of medicine at the University of Missouri School of Medicine.
The results show that only in men did the sedentary lifestyle and high sugar intake cause decreased insulin-stimulated leg blood flow and a drop in a protein called adropin, which regulates insulin sensitivity and is an important biomarker for cardiovascular disease.
“These findings underscore a sex-related difference in the development of vascular insulin resistance induced by adopting a lifestyle high in sugar and low on exercise,” says Manrique-Acevedo. “To our knowledge, this is the first evidence in humans that vascular insulin resistance can be provoked by short-term adverse lifestyle changes, and it’s the first documentation of sex-related differences in the development of vascular insulin resistance in association with changes in adropin levels.”
Manrique-Acevedo says she would next like to examine how long it takes to reverse these vascular and metabolic changes and more fully assess the impact of the role of sex in the development of vascular insulin resistance.
Their study appears in the journal Endocrinology. Part of the support for this study came from the National Institutes of Health and a VA Merit Grant. The content does not necessarily represent the official views of the funding agency. The authors declare no potential conflicts of interest.
Source: University of Missouri
Original Study DOI: 10.1210/endocr/bqac137
—
This post was previously published on FUTURITY.ORG and is republished here under a Creative Commons license.
***
From The Good Men Project on Medium
What Does Being in Love and Loving Someone Really Mean? 
My 9-Year-Old Accidentally Explained Why His Mom Divorced Me 
The One Thing Men Want More Than Sex 
The Internal Struggle Men Battle in Silence Join The Good Men Project as a Premium Member today.
All Premium Members get to view The Good Men Project with NO ADS.
A $50 annual membership gives you an all access pass. You can be a part of every call, group, class and community.
A $25 annual membership gives you access to one class, one Social Interest group and our online communities.
A $12 annual membership gives you access to our Friday calls with the publisher, our online community.
Register New Account
Log in if you wish to renew an existing subscription.
Username
First Name
Last Name
Password
Password Again
Choose your subscription level
- Yearly - $50.00 - 1 Year
- Monthly - $6.99 - 1 Month
Credit / Debit Card PayPal Choose Your Payment Method
Auto Renew
Subscribe to The Good Men Project Daily Newsletter By completing this registration form, you are also agreeing to our Terms of Service which can be found here.Need more info? A complete list of benefits is here.
—
Photo credit: iStock.com
The post How a Sedentary, Sugary Period Affects the Body appeared first on The Good Men Project.
Original Article
